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3-(4-Chlorophenyl)quinoxaline-5-carboxamide

PARP inhibitor
 
ALX-270-486-M005 5 mg 363.00 USD
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Potent quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 (IC50=7nM) over PARP-1 (IC50=33nM). Brain-permeant. Exhibits good pharmacokinetics.

Product Specification

Formula:C15H10ClN3O
 
MW:283.7
 
CAS:489457-67-2
 
Purity:≥95% (HPLC)
 
Appearance:Light brown solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light. Packaged under inert gas.
 
270-486
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270-486

Product Literature References

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling: J. Ishida, et al.; Bioorg. Med. Chem. 14, 1378 (2006), Abstract;
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors: A. Iwashita, et al.; FEBS Lett. 579, 1389 (2005), Abstract;

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The PARP Family & ADP Ribosylation
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