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B2

SIRT2 inhibitor
 
ALX-270-485-MC05 0.5 mg 30.00 USD
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Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC50=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Product Specification

Alternative Name:CPNQ, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
 
Formula:C20H17ClN4O3
 
MW:396.8
 
CAS:115687-05-3
 
Purity:≥95%
 
Identity:Determined by MS, 1H- and 13C-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (>5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and oxygen.
 
270-485
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270-485

Product Literature References

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases: R.A. Bodner, et al.; PNAS 103, 4246 (2006), Abstract; Full Text

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