B2

SIRT2 inhibitor



ALX-270-485-MC05	0.5 mg	19.00 USD

ALX-270-485-M005	5 mg	101.00 USD

Cell permeable inhibitor of sirtuin 2 (SIRT2) (IC₅₀=35μM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Product Specification

Alternative Name:	CPNQ, 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Identity:	Identity determined by MS, ¹H- and ¹³C-NMR.

Formula:	C₂₀H₁₇ClN₄O₃

MW:	396.8

Purity:	≥95%

Appearance:	Yellow solid.

CAS:	115687-05-3

Solubility:	Soluble in DMSO (>5mg/ml).

Long Term Storage:	-20°C

Hazard:	TOXIC.

Handling:	Protect from light and oxygen.

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Product Literature References

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington’s and Parkinson’s diseases: R.A. Bodner, et al.; PNAS 103, 4246 (2006), Abstract; Full Text