AGK2

SIRT2 inhibitor



ALX-270-484-M001	1 mg	42.00 USD

ALX-270-484-M005	5 mg	124.00 USD

Potent, selective and cell permeable inhibitor of sirtuin 2 (SIRT2) (IC₅₀=3.5μM). Rescues α-synuclein-mediated toxicity. Modifies inclusion morphology in a cellular model of Parkinson’s disease. Protects against dopaminergic cell death. Leads to an increase in acetylated tubulin.

Product Specification

Alternative Name:	2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

Identity:	Identity determined by MS, ¹H- and ¹³C-NMR.

Formula:	C₂₃H₁₃Cl₂N₃O₂

MW:	434.3

Purity:	≥95%

Appearance:	Yellow solid.

CAS:	304896-28-4

Solubility:	Soluble in DMSO (>5mg/ml).

Long Term Storage:	-20°C

Handling:	Protect from light.

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Product Literature References

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson’s disease: T.F. Outeiro, et al.; Science 317, 516 (2007), Abstract;