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WP1066

STAT3 inhibitor. Bax activator.
 
ALX-270-483-M001 1 mg 217.00 USD
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Cell permeable STAT3 inhibitor. Activates Bax. Shows potent anticancer effect on malignant glioma cells. Induces apoptosis and inhibits the growth of tumors. Acts as a potent immune adjuvant by upregulating CD80 and CD86 and inducing proliferation of effector T cells.

Product Specification

Alternative Name:3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2-propenamide
 
Formula:C17H14BrN3O
 
MW:356.2
 
CAS:857064-38-1
 
Purity:≥95%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (>5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
270-483
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270-483

Product Literature References

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo: A. Iwamaru, et al.; Oncogene 26, 2435 (2007), Abstract;
A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients: S.F. Hussain, et al.; Cancer Res. 67, 9630 (2007), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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