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Fenofibrate

PPARα activator
 
ALX-270-481-G005 5 g 39.00 USD
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Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist (EC50=18µM for mouse and EC50=30µM for human PPARα). Also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ (up to EC50=100µM).

Product Specification

Alternative Name:2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic acid 1-methylethyl ester, Procetofen
 
Formula:C20H21ClO4
 
MW:360.8
 
CAS:49562-28-9
 
MI:14: 3978
 
RTECS:UA2453400
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in acetone, ether, DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-481
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Product Literature References

Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis and elongation in mice: M.H. Oosterveer, et al.; J. Biol. Chem. 284, 34036 (2009), Abstract;
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008), Abstract; Full Text
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006), Abstract; Full Text
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006), Abstract; Full Text
Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999), Abstract;
Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981), Abstract;

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