Caffeic acid ethyl ester



ALX-270-480-M050	50 mg	30.00 USD

ALX-270-480-M250	250 mg	60.00 USD

Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC₅₀=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E₂ (PGE₂) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H₂O₂.

Product Specification

Alternative Name:	CAEE, Ethyl caffeate

Formula:	C₁₁H₁₂O₄

MW:	208.2

Purity:	≥99% (GC)

Appearance:	Off-white to brown solid.

CAS:	66648-50-8

Source/Host:	Synthetic.

Long Term Storage:	-20°C

Use/Stability:	Stable for at least one year after receipt when stored at -20°C.

Hazard:	IRRITANT.

Handling:	Protect from light and moisture.

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Product Literature References

Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines: M. Cardenas, et al.; Bioorg. Med. Chem. 14, 2966 (2006), Abstract;

Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006), Abstract;

Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin: Y.M. Chiang, et al.; Br. J. Pharmacol. 146, 352 (2005), Abstract;

Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells: T. Nakayama, et al.; Biosci. Biotechnol. Biochem. 60, 316 (1996), Abstract;