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BAY 61-3606 . hydrochloride

Syk inhibitor
 
ALX-270-479-M001 1 mg 49.00 USD
 
ALX-270-479-M005 5 mg 177.00 USD
 
ALX-270-479-M025 25 mg 694.00 USD
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Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.

Product Specification

Alternative Name:2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl
 
Formula:C20H18N6O3 . HCl
 
MW:390.4 . 36.5
 
CAS:648903-57-5
 
Purity:≥98% (HPLC(UV))
 
Identity:Determined by MS.
 
Appearance:Yellow solid.
 
Solubility:Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Hygroscopic.
 
270-479
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270-479

Product Literature References

Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck: S. Luangdilok, et al.; Cancer Res. 67, 7907 (2007), Abstract;
Kinase inhibitors and airway inflammation: I.M. Adcock, et al.; Eur. J. Pharmacol. 533, 118 (2006), Abstract;
A novel Syk kinase-selective inhibitor blocks antigen presentation of immune complexes in dendritic cells: K. Nakashima, et al.; Eur. J. Pharmacol. 505, 223 (2004), Abstract;
Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases: P. Luskova & P. Draber; Curr. Pharm. Des. 10, 1727 (2004), Abstract;
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents: N. Yamamoto, et al.; J. Pharmacol. Exp. Ther. 306, 1174 (2003), Abstract; Full Text

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