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SB 225002

Chemokine receptor ligand
 
ALX-270-478-M001 1 mg 36.00 USD
 
ALX-270-478-M005 5 mg 105.00 USD
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Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.

Product Specification

Alternative Name:N-(2-Bromophenyl)-N’-(2-hydroxy-4-nitrophenyl)urea
 
Formula:C13H10BrN3O4
 
MW:352.1
 
CAS:182498-32-4
 
Purity:≥98% (HPLC)
 
Identity:Identity determined by MS, 1H-NMR and 13C-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (40mg/ml), 100% ethanol or methanol (15mg/ml); slightly soluble in acetonitrile (2mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-478
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270-478

Product Literature References

CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1: S. Braber, et al.; Eur. J. Pharmacol. 668, 443 (2011), Abstract;
A growth-related oncogene/CXC chemokine receptor 2 autocrine loop contributes to cellular proliferation in esophageal cancer: B. Wang, et al.; Cancer Res. 66, 3071 (2006), Abstract; Full Text
Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen alpha (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2: J. Catusse, et al.; Biochem. Pharmacol. 65, 813 (2003), Abstract;
Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration: J.R. White, et al.; J. Biol. Chem. 273, 10095 (1998), Abstract; Full Text

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