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PD 184,352

 
ALX-270-471-M001 1 mg 103.00 USD
 
ALX-270-471-M005 5 mg 420.00 USD
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Potent and selective inhibitor of MAPK (ERK kinase 1; MEK1) activation (IC50=300nM in vitro, IC50=2nM in vivo). Suppresses activation of MAPK but does not block its activity. Strongly suppresses growth of human implanted colon tumors in mice.

Product Specification

Alternative Name:2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040
 
Formula:C17H14ClF2IN2O2
 
MW:478.7
 
Source:Synthetic.
 
CAS:212631-79-3
 
Purity:≥95% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in organic solvents.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-471
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270-471

Product Literature References

Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2’-deoxyguanosine and Nitrotyrosine in Melanoma: H.R. Hintsala, et al.; Anticancer Res. 36, 1497 (2016), Application(s): Inhibiting MEK1/MEK2 by blocking ERK phosphorylation, Abstract; Full Text
Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation: A. Breit, et al.; Mol. Endocrinol. 29, 445 (2015), Application(s): Western Blotting, Abstract; Full Text
The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer: P.J. Klein, et al.; Neoplasia 8, 1 (2006), Abstract; Full Text
Effects of the MEK inhibitor CI-1040 (PD 184352) on progenitor growth from normal and myelodysplastic marrow: D.P. Steensma, et al.; Haematologica 88, 1072 (2003), Abstract;
Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352: A.M. Delaney, et al.; Mol. Cell. Biol. 22, 7593 (2002), Abstract; Full Text
Specificity and mechanism of action of some commonly used protein kinase inhibitors: S.P. Davies, et al.; Biochem. J. 351, 95 (2000), Abstract; Full Text
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo: J.S. Sebolt-Leopold, et al.; Nat. Med. 5, 810 (1999), Abstract;

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