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BAY 43-9006

Broad-spectrum kinase inhibitor
 
ALX-270-469-M001 1 mg 69.00 USD
 
ALX-270-469-M005 5 mg 275.00 USD
 
ALX-270-469-M025 25 mg 840.00 USD
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Broad-spectrum kinase inhibitor.

Product Specification

Alternative Name:N-[4-Chloro-3-(trifluoromethyl)phenyl]-([4-[2-(N-methylcarbamoyl)(4-pyridyloxy)]phenyl]amino)-carboxamide, Sorafenib
 
Formula:C21H16ClF3N4O3
 
MW:464.8
 
Source:Synthetic.
 
CAS:284461-73-0
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by 1H-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO, 100% ethanol, methanol or ethyl acetate.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-270-469 structure
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ALX-270-469 structure

Product Literature References

The kinase inhibitor Sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress: M. Rahmani, et al.; Mol. Cell. Biol. 27, 5499 (2007), Abstract;
Sorafenib (BAY 43-9006, Nexavar((R))), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature: L. Adnane, et al.; Meth. Enzymol. 407, 597 (2005), Abstract;

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