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AS-252424

PI3 kinase p110γ inhibitor
 
ALX-270-465-M001 1 mg 38.00 USD
 
ALX-270-465-M005 5 mg 145.00 USD
 
ALX-270-465-M025 25 mg 479.00 USD
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Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.

Product Specification

Alternative Name:5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione
 
Formula:C14H8FNO4S
 
MW:305.3
 
CAS:900515-16-4
 
Purity:≥98% (1H-NMR)
 
Appearance:Yellow-green to brownish solid.
 
Solubility:Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receip when stored at -20°C.
 
270-465
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Product Literature References

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract;
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma: V. Pomel, et al.; J. Med. Chem. 49, 3857 (2006), Abstract; Full Text
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood 106, 1432 (2005), Abstract; Full Text

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