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RO-3306

CDK/cyclin inhibitor
 
ALX-270-463-M001 1 mg 59.00 USD
 
ALX-270-463-M005 5 mg 245.00 USD
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Inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. Reversibly arrests human cells at the G2/M border of the cell cycle. Allows for effective cell synchronisation in early mitosis. Downregulates expression of the antiapoptotic proteins Bcl-2 and survivin and blocks p53-mediated induction of p21 and MDM2.

Product Specification

Alternative Name:(5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
 
Formula:C18H13N3OS2
 
MW:351.4
 
CAS:872573-93-8
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Brown solid.
 
Solubility:Soluble in DMSO (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months after receipt when stored at -20°C in the dark.
 
Handling:Protect from light.
 
270-463
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Product Literature References

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells: C. Lopes, et al.; PLoS One. 11, e0148680 (2016), Application(s): Cell culture, Abstract; Full Text
MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity: X. Chen, et al.; Cell. Signal. 28, 1826 (2016), Application(s): CDK1 Inhibitor, identification of the corresponding kinase for MST2 phosphorylation, Abstract;
Phosphorylation of Astrin regulates its Kinetochore Function: H. Chung, et al.; J. Biol. Chem. 291, 17579 (2016), Application(s): Cell culture for kinase inhibition, Abstract; Full Text
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis: S. Meunier, et al.; Nat. Commun. 6, 7889 (2015), Application(s): Cell synchronization, Abstract;
JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis: H. Tuncay, et al.; Nat. Commun. 6, 8128 (2015), Application(s): Cell culture , Abstract; Full Text
Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Upregulation of BubR1: S. Yang, et al.; J. Biol. Chem. 290, 6191 (2015), Application(s): Cell Culture, Abstract; Full Text
Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML: K. Kojima, et al.; Cancer Sci. 100, 1128 (2009), Abstract;
Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1: L.T. Vassilev; Cell Cycle 5, 2555 (2006), Abstract; Full Text
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1: L.T. Vassilev, et al.; PNAS 103, 10660 (2006), Abstract; Full Text

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