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AS-605240

PI3 kinase p110γ inhibitor
 
ALX-270-462-M005 5 mg 88.00 USD
 
ALX-270-462-M025 25 mg 319.00 USD
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Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.

Product Specification

Alternative Name:5-Quinoxalin-6-ylmethylene-thiazolidine-2,4-dione
 
Formula:C12H7N3O2S
 
MW:257.3
 
CAS:648450-29-7
 
Purity:≥95% (1H-NMR)
 
Appearance:Pink to reddish brown solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
270-462
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270-462

Product Literature References

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005), Abstract;
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus: D.F. Barber, et al.; Nat. Med. 11, 933 (2005), Abstract;

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