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PI-103

Inhibitor of DNA-PK, PI3 kinase and mTOR
 
ALX-270-460-M001 1 mg 45.00 USD
 
ALX-270-460-M005 5 mg 134.00 USD
 
ALX-270-460-M025 25 mg 323.00 USD
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Potent, cell permeable and ATP-competitive inhibitor of DNA-PK, phosphoinositide 3-kinase (PI(3)K), the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. Exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10µM. Effectively blocks cell proliferation in glioma cell lines both in vitro and in vivo.

Product Specification

Alternative Name:3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
 
Formula:C19H16N4O3
 
MW:348.4
 
CAS:371935-74-9
 
Purity:≥97% (HPLC)
 
Identity:Identity determined by MS and NMR.
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (5mg/ml; warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
 
270-460
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270-460

Product Literature References

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood 117, 5953 (2011), Abstract; Full Text
Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia: F. Chiarini, et al.; Cancer Res. 69, 3520 (2009), Abstract;
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma: Q.W. Fan, et al.; Cancer Cell 9, 341 (2006), Abstract;
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling: Z.A. Knight, et al.; Cell 125, 733 (2006), Abstract;

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