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Compound 15e

PI3 kinase inhibitor
 
ALX-270-455-M001 1 mg 55.00 USD
 
ALX-270-455-M005 5 mg 222.00 USD
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Potent and specific inhibitor of phosphoinositide 3-kinasep110α isoform (IC50=0.0020µM). p110β isoform (IC50=0.016µM)p110γ isoform (IC50=0.66µM)C2β isoform (IC50=0.22µM). Inhibits proliferation of A375 melanoma cells (IC50=0.58µM). Inhibits proliferation of U87MG human glioblastoma cells (IC50=1.10.µM).Inhibits proliferation of A2780 human ovarian cells (IC50=0.27µM).

Product Specification

Alternative Name:3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
 
Formula:C16H15N3O2S
 
MW:313.4
 
CAS:371943-05-4
 
Purity:≥99% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO or dioxane.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-455
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Product Literature References

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin -4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer: A.J. Folkes; J. Med. Chem. 51, 5522 (2008), Abstract;
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors: M. Hayakawa, et al.; Bioorg. Med. Chem. 14, 6847 (2006), Abstract;

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