Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

ZSTK474

Inhibits all four PI3K isoforms.
 
ALX-270-454-M005 5 mg 71.00 USD
 
ALX-270-454-M010 10 mg 115.00 USD
Do you need bulk/larger quantities?
 
Cell permeable, reversible, potent and specific inhibitor of phosphoinositide 3-kinase (IC50=17nM for PI(3)K p110β, IC50=53nM for PI(3)K p110γ and IC50=6nM for PI(3)K p110δ). Blocks cellular PI(3)K/Akt (PKB) signalling in vitro and inhibits Akt(PKB)-dependent tumor growth in mice in vivo without significant toxic effect. More effective than LY 294,002 (Prod. No. BML-ST420) in vitro and as in vivo.

Product Specification

Alternative Name:2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
 
Formula:C19H21F2N7O2
 
MW:417.4
 
CAS:475110-96-4
 
Purity:≥98% (HPLC)
 
Identity:Determined by EM-MS and NMR.
 
Appearance:White powder.
 
Solubility:Soluble in DMSO (21mg/ml). Sparingly soluble in ethanol (<1mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from light.
 
ALX-270-454 structure
Please mouse over
ALX-270-454 structure

Product Literature References

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor: S. Yaguchi, et al.; J. Natl. Cancer Inst. 98, 545 (2006), Abstract;
A novel phosphatidylinositol 3-kinase inhibitor, ZSTK474 exerted antitumor activity against human tumor xenografts by oral administration: S. Yaguchi, et al.; Proc. Am. Assoc. Cancer Res. 46, 1691 (2005), Abstract;

Related Products

LY 294002 

PI3 kinase inhibitor
154447-36-6, ≥98% (HPLC) | Print as PDF
 
BML-ST420-0005 5 mg 110.00 USD
 
BML-ST420-0025 25 mg 417.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
PI3 kinase
By biological activity:
PI3 kinase Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,