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DR2313

PARP inhibitor
 
ALX-270-452-M005 5 mg 72.00 USD
 
ALX-270-452-M025 25 mg 194.00 USD
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Potent, water soluble competitive PARP inhibitor (IC50=0.20µM and 0.24µM for PARP-1 and PARP-2 respectively).

Product Specification

Alternative Name:2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
 
Formula:C8H10N2OS
 
MW:182.2
 
CAS:284028-90-6
 
Purity:≥98% (HPLC (UV))
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in DMSO, methanol or water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Protect from light. After reconstitution, prepare aliquots and store at -20°C.
 
270-452
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270-452

Product Literature References

A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats: H. Nakajima, et al.; Pharmacol. Exp. Ther. 312, 472 (2005), Abstract; Full Text

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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