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AS601245

Jnk inhibitor
 
ALX-270-443-M001 1 mg 56.00 USD
 
ALX-270-443-M005 5 mg 166.00 USD
 
ALX-270-443-M025 25 mg 625.00 USD
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Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50=150nM, hJNK2: IC50=220nM and hJNK3: IC50=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.

Product Specification

Alternative Name:1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile, JNK Inhibitor V
 
Formula:C20H16N6S
 
MW:372.5
 
CAS:345987-15-7
 
Purity:≥95% (HPLC)
 
Purity Detail:Sum of two isomers.
 
Identity:Determined by 1H-NMR.
 
Appearance:White to yellow solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 3 months when stored at -20°C.
 
Handling:Hygroscopic. Packaged under inert gas. Protect from light.
 
270-443
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270-443

Product Literature References

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4: R. Kamata, et al.; PLoS One 11, e0165132 (2016), Application(s): Cell culture, Mouse aortic SMCs , Abstract; Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005), Abstract;
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004), Abstract; Full Text

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