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CDK1/2 Inhibitor III

 
ALX-270-442-M001 1 mg 220.00 USD
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Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC50=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC50=32nM and 140nM).

Product Specification

Alternative Name:5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
 
Formula:C15H13F2N7O2S2
 
MW:425.4
 
CAS:443798-55-8
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml), tetrahydrofuran or acetone.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from light.
 
270-442
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270-442

Product Literature References

1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities: R. Lin, et al.; J. Med. Chem. 48, 4208 (2005), Abstract;

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