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CDK/cyclin inhibitor
ALX-270-441-M005 5 mg 161.00 USD
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Highly cell permeable purine compound that acts as a selective and ATP-competitive inhibitor of CDKs (IC50=6.6µM, 0.41µM, 5.5µM, 15µM and 3.9µM for CDK1/cyclin B, CDK2/cyclin A, CDK4/cyclin D, CDK5/p25 and CDK7/cyclin H) and displays anticancer properties. Causes cell cycle arrest at the G2/M phase and induces apoptosis by activating caspases and downregulating survivin.

Product Specification

Alternative Name:4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
Purity:≥95% (HPLC)
Identity:Determined by 1H-NMR and MS.
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (10mg/ml).
Long Term Storage:+4°C
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
Handling:Protect from light. Packaged under inert gas.
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Product Literature References

Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation: M. Pennati, et al.; Mol. Cancer Ther. 4, 1328 (2005), Abstract;

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