United States
AMI-1
PRMT inhibitor
| ALX-270-440-M005 | 5 mg | 93.00 USD |  |
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| ALX-270-440-M025 | 25 mg | 371.00 USD | |
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Potent, cell permeable and specific inhibitor of protein arginine N-methyltransferases (PRMTs) (IC50=8.8µM for human PRMT1 and 3.0µM for yeast Hmt1p). Does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site. Exhibits only minimal effects on lysine N-methyltransferases. Suppresses the transcriptional coactivator activity of PRMT1 and PRMT4. Inhibitor of HIV-1 RT polymerase (IC50=5.0µM).
Product Specification
| Alternative Name: | Arginine N-Methyltransferase Inhibitor-1 |
| Formula: | C21H12N2O9S2Na4 |
| MW: | 592.4 |
| Purity: | ≥98% (1H-NMR and HPLC) |
| Appearance: | Brown solid. |
| Solubility: | Soluble in water, 100% ethanol or DMSO. |
| Long Term Storage: | -20°C |
| Handling: | After reconstitution, prepare aliquots and store at -20°C. Hygroscopic. Protect from light. |
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Product Literature References
Small molecule regulators of protein arginine methyltransferases: D. Cheng, et al.; J. Biol. Chem. 279, 23892 (2004), Abstract; Full Text
A novel mechanism for inhibition of HIV-1 reverse transcriptase: A.G. Skillman, et al.; Bioorg. Chem. 30, 443 (2002), Abstract;
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