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Mitotic kinesin Eg5 inhibitor
 
ALX-270-439-M001 1 mg 91.00 USD
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Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=650nM) by binding to the mitotic kinesin Eg5.

Product Specification

Alternative Name:(5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-β-carboline-1,3-dione
 
Formula:C26H21N3O3
 
MW:423.5
 
CAS:869304-55-2
 
Purity:≥95%
 
Identity:Identity determined by MS, 1H- and 13C-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months when stored at -20°C in the dark.
 
Handling:Protect from light.
 
270-439
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270-439

Product Literature References

Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem. 13, 6094 (2005), Abstract;

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Kinesin
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Kinesin Inhibitor
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