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Dimethylenastron

Mitotic kinesin Eg5 inhibitor
 
ALX-270-438-M001 1 mg 96.00 USD
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Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=200nM) by binding to the mitotic kinesin Eg5.

Product Specification

Alternative Name:7,7-Dimethyl-4-(3-hydroxyphenyl)-5-oxo-3,4,5,6,7,8-hexahydroquinazolin-2(1H)-thione
 
Formula:C16H18N2O2S
 
MW:302.4
 
CAS:863774-58-7
 
Purity:≥95%
 
Identity:Determined by MS, 1H- and 13C-NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (10mg/ml) or methanol (5mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months when stored at -20°C in the dark.
 
Handling:Protect from light.
 
270-438
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270-438

Product Literature References

Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells: C. Muller, et al.; Cancer Chemother. Pharmacol. 59, 157 (2007), Abstract;
Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5: M. Gartner, et al.; ChemBioChem. 6, 1173 (2005), Abstract;
Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5: N. Sunder-Plassmann, et al.; Bioorg. Med. Chem. 13, 6094 (2005), Abstract;

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