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1-Azakenpaullone

GSK-3β inhibitor
 
ALX-270-430-M001 1 mg 106.00 USD
 
ALX-270-430-M005 5 mg 457.00 USD
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Analog of kenpaullone (Prod. No. BML-EI310) acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on GSK-3β than over CDK1/cyclin B and CDK5/p25 (IC50=2.0µM and 4.2µM, respectively).

Product Specification

Alternative Name:9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 1-AKP
 
Formula:C15H10BrN3O
 
MW:328.2
 
CAS:676596-65-9
 
Purity:≥95% (HPLC, TLC)
 
Appearance:Off-white to brown powder.
 
Solubility:Soluble in DMSO; insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for up to 6 months when stored at -20°C.
 
Handling:Protect from moisture. Protect from light.
 
270-430
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270-430

Product Literature References

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta: T. Hirota, et al.; PNAS USA 105, 20746 (2008), Abstract; Full Text
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lett. 15, 823 (2005), Abstract;
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta: C. Kunick, et al.; Bioorg. Med. Chem. Lett. 14, 413 (2004), Abstract;

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