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United States 

SC-560

COX inhibitor
 
ALX-270-427-M005 5 mg 66.00 USD
 
ALX-270-427-M025 25 mg 236.00 USD
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Selective COX-1 inhibitor (IC50=9nM). Shows 700-fold more selectivity over COX-2 (IC50=6.3µM). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2, and dermal PGE2 production. Orally active in rat.

Product Specification

Alternative Name:5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
 
Formula:C17H12N2OClF3
 
MW:352.7
 
CAS:188817-13-2
 
Purity:≥98%
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receipt when stored at –20°C.
 
270-427
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270-427

Product Literature References

Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo: W. Li, et al.; Int. J. Mol. Sci. 12, 668 (2011), Abstract; Full Text
Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression: K. Soontrapa, et al.; PNAS U.S.A. 108, 6668 (2011), Abstract; Full Text
Pharmacological analysis of cyclooxygenase-1 in inflammation: C.J. Smith, et al.; PNAS 95, 13313 (1998), Abstract; Full Text
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994), Abstract; Full Text

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