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SAG

Smoothened ligand
 
ALX-270-426-M001 1 mg 235.00 USD
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A potent cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50= ~3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine (BML-GR334) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.

Product Specification

Formula:C28H28ClN3OS
 
MW:490.1
 
CAS:364590-63-6
 
Purity:≥95% (HR-MS, 1H-NMR, 13C-NMR)
 
Identity:Determined by HR-MS, 1H- and 13C-NMR. 
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml), sparingly soluble in water (acidification with HCl increases water solubility).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 6 months when stored at -20°C.
 
270-426
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Product Literature References

Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells: C. Ozone, et al.; Nat. Commun. 7, Article number 10351 (2016), Application(s): Cell culture, Abstract;
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups: D.A. Parfitt, et al.; Cell Stem Cell 18, 769 (2016), Application(s): Cell culture, Abstract;
Sequential Differentiation of Embryonic Stem Cells into Neural Epithelial-Like Stem Cells and Oligodendrocyte Progenitor Cells: J. Bian, et al.; PLoS One 11, e0155227 (2016), Application(s): Cell culture, Abstract; Full Text
Modeling amyotrophic lateral sclerosis in pure human iPSc-derived motor neurons isolated by a novel FACS double selection technique: D. Toli, et al.; Neurobiol. Dis. 82, 269 (2015), Application(s): Cell Culture, Abstract;
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals: T. Danjo, et al.; J. Neurosci. 31, 1919 (2011), Abstract;
Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3: Y. Asoaka, et al.; J. Biol. Chem. 285, 4185 (2010), Abstract; Full Text
Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA: F.K. Noubissi, et al.; Cancer Res. 69, 8572 (2009), Abstract; Full Text
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells: R.B. Corcoran and M.P. Scott; PNAS 103, 8408 (2006), Abstract; Full Text
Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2: A.R. Meloni et al.; Mol Cell Biol. 26, 7550 (2006), Abstract;
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2: W. Chen, et al.; Science 306, 2257 (2004), Abstract;
Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002), Abstract; Full Text
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: M. Frank-Kamenetsky, et al.; J. Biol. 1, 10 (2002), Abstract; Full Text

Related Products

Cyclopamine 

Blocks Hedgehog signaling
4449-51-8, ≥98% (TLC) | Print as PDF
 
BML-GR334-0001 1 mg 111.00 USD
 
BML-GR334-0005 5 mg 445.00 USD
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