SAG



ALX-270-426-M001	1 mg	195.00 USD

Potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.

Product Specification

Identity:	Identity determined by HR-MS, ¹H- and ¹³C-NMR.

Formula:	C₂₈H₂₈ClN₃OS

MW:	490.1

Purity:	≥95% (HR-MS, ¹H-NMR, ¹³C-NMR)

Appearance:	White to off-white solid.

CAS:	364590-63-6

Solubility:	Soluble in water (5mg/ml) or DMSO (10mg/ml).

Shipping:	AMBIENT

Long Term Storage:	-20°C

Handling:	Protect from light.

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Product Literature References

Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002), Abstract; Full Text

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: M. Frank-Kamenetsky, et al.; J. Biol. 1, 10 (2002), Abstract; Full Text

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2: W. Chen, et al.; Science 306, 2257 (2004), Abstract;

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells: R.B. Corcoran and M.P. Scott; PNAS 103, 8408 (2006), Abstract; Full Text

Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2: A.R. Meloni et al.; Mol Cell Biol. 26, 7550 (2006), Abstract;