SAG - Enzo Life Sciences

ALX-270-426

Revised 01-Feb-10

SAG
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Hedgehog [Hh] Signalling Pathway

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-426-M001		1 mg	195.00 USD

Product Specification

FORMULA:	C₂₈H₂₈ClN₃OS
MW:	490.1
CAS NUMBER:	364590-63-6
PURITY:	≥95% (HR-MS, ¹H-NMR, ¹³C-NMR)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water (5mg/ml) or DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Identity determined by HR-MS, ¹H- and ¹³C-NMR.

Product Description

Potent agonist of Hedgehog (Hh) signalling by activating the Smoothened (Smo) protein function.

Product Specific Literature References

Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) Abstract; Full Text
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists: M. Frank-Kamenetsky, et al.; J. Biol. 1, 10 (2002) Abstract; Full Text
Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2: W. Chen, et al.; Science 306, 2257 (2004) Abstract
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells: R.B. Corcoran and M.P. Scott; PNAS 103, 8408 (2006) Abstract; Full Text
Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2: A.R. Meloni et al.; Mol Cell Biol. 26, 7550 (2006) Abstract