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Indirubin-3’-(2,3-dihydroxypropyl)oximether

Src kinase inhibitor
 
ALX-270-425-M001 1 mg 132.00 USD
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Inhibitor of c-Src (IC50=0.43µM) blocking downstream STAT3 signalling. Induces apoptosis in human cancer cells.

Product Specification

Alternative Name:E804
 
Formula:C19H17N3O4
 
MW:351.4
 
Purity:≥96% (1H-NMR)
 
Identity:Determined by 1H-NMR and 13C-NMR.
 
Appearance:Dark red solid.
 
Solubility:Soluble in DMSO (1M).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-425
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270-425

Product Literature References

Effects of the Indirubin Derivative E804 on Glioblastoma Associated Immunomodulation: H. Houke; (2016), (master's thesis), Application(s): Cytotoxicity assay and effects on protein expression, Full Text
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells: S. Nam, et al.; PNAS 102, 5998 (2005), Abstract;

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