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5-Iodo-indirubin-3'-monoxime

Inhibitor of GSK and CDK/cyclin
 
ALX-270-424-M001 1 mg 112.00 USD
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Potent inhibitor of GSK-3β (IC50=9nM). Also inhibits CDK1/cyclin B (IC50=25nM) and CDK5/p25 (IC50=20nM) by binding to the ATP-binding pocket.

Product Specification

Formula:C16H10IN3O2
 
MW:403.2
 
Purity:≥98% (1H-NMR)
 
Identity:Determined by 1H-NMR and 13C-NMR.
 
Appearance:Dark red solid.
 
Solubility:Soluble in DMSO (1M).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
270-424
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270-424

Product Literature References

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract; Full Text

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