5-Iodo-indirubin-3'-monoxime

Inhibitor of GSK and CDK/cyclin



ALX-270-424-M001	1 mg	101.00 USD

Potent inhibitor of GSK-3β (IC₅₀=9nM). Also inhibits CDK1/cyclin B (IC₅₀=25nM) and CDK5/p25 (IC₅₀=20nM) by binding to the ATP-binding pocket.

Product Specification

Formula:	C₁₆H₁₀IN₃O₂

MW:	403.2

Purity:	≥98% (¹H-NMR)

Appearance:	Dark red solid.

Solubility:	Soluble in DMSO (1M).

Long Term Storage:	-20°C

Handling:	Protect from light.

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Product Literature References

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract; Full Text