ABH . ammonium salt

Arginase inhibitor



ALX-270-420-M001	1 mg	57.00 USD

ALX-270-420-M005	5 mg	248.00 USD

Potent and specific inhibitor of arginase. Does not inhibit NO synthases.

Product Specification

Alternative Name:	2(S)-Amino-6-boronohexanoic acid . NH₄

Formula:	C₆H₁₃BNO₄ . NH₄

MW:	174.0 . 18.0

Purity:	≥95.0% (¹H-NMR)

Appearance:	White to off-white powder.

Solubility:	Soluble in water.

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Solutions are stable for 6 months when stored at -20°C.

Handling:	After reconstitution, prepare aliquots and store at -20°C. Hygroscopic.

Background / Technical Information:	Note: Can contain up to 15% ammonium chloride. This does not affect activity, but must be taken into account for calculation of concentrations.

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Product Literature References

Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005), Abstract; Full Text

Role of arginase in the male and female sexual arousal response: N.N. Kim, et al.; J. Nutr. 134, 2873S (2004), Abstract; Full Text

Arginase and autoimmune inflammation in the central nervous system: L. Xu, et al.; Immunology 110, 141 (2003), Abstract; Full Text

Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans: P. Stickings, et al.; Nitric Oxide 7, 289 (2002), Abstract;

Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori and D.E. Ash; Biochemistry (Mosc). 40, 9356 (2001), Abstract;

Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction: T.J. Bivalacqua, et al.; BBRC 283, 923 (2001), Abstract;

Arginase-boronic acid complex highlights a physiological role in erectile function: J.D. Cox, et al.; Nat. Struct. Biol. 6, 1043 (1999), Abstract;

Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor: R. Baggio, et al.; J. Pharmacol. Exp. Ther. 290, 1409 (1999), Abstract; Full Text

Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analog inhibitor, 2(S)-amino-6-boronohexanoic acid: R. Baggio, et al.; J. Am. Chem. Soc. 119, 8107 (1997),