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ABH . ammonium salt

Arginase inhibitor
 
ALX-270-420-M001 1 mg 66.00 USD
 
ALX-270-420-M005 5 mg 289.00 USD
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Potent and specific inhibitor of arginase. Does not inhibit NO synthases.

Product Specification

Alternative Name:2(S)-Amino-6-boronohexanoic acid . NH4
 
Formula:C6H13BNO4 . NH4
 
MW:174.0 . 18.0
 
Purity:≥95.0% (1H-NMR)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Use/Stability:Solutions are stable for 6 months when stored at -20°C.
 
Handling:Hygroscopic. After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:Note: Can contain up to 15% ammonium chloride. This does not affect activity, but must be taken into account for calculation of concentrations.
 
270-420
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270-420

Product Literature References

Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response: L. Di Costanzo, et al.; PNAS 102, 13058 (2005), Abstract; Full Text
Role of arginase in the male and female sexual arousal response: N.N. Kim, et al.; J. Nutr. 134, 2873S (2004), Abstract; Full Text
Arginase and autoimmune inflammation in the central nervous system: L. Xu, et al.; Immunology 110, 141 (2003), Abstract; Full Text
Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans: P. Stickings, et al.; Nitric Oxide 7, 289 (2002), Abstract;
Classical and slow-binding inhibitors of human type II arginase: D.M. Colleluori and D.E. Ash; Biochemistry (Mosc). 40, 9356 (2001), Abstract;
Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction: T.J. Bivalacqua, et al.; BBRC 283, 923 (2001), Abstract;
Arginase-boronic acid complex highlights a physiological role in erectile function: J.D. Cox, et al.; Nat. Struct. Biol. 6, 1043 (1999), Abstract;
Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor: R. Baggio, et al.; J. Pharmacol. Exp. Ther. 290, 1409 (1999), Abstract; Full Text
Inhibition of Mn2+ 2-arginase by borate leads to the design of a transition state analog inhibitor, 2(S)-amino-6-boronohexanoic acid: R. Baggio, et al.; J. Am. Chem. Soc. 119, 8107 (1997),

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