Compound 34

γ-Secretase inhibitor



ALX-270-417-C200	200 µg	76.00 USD

ALX-270-417-M001	1 mg	248.00 USD

Cell permeable, highly potent inhibitor of γ-secretase (IC₅₀=0.06nM).

Product Specification

Alternative Name:	(2S,3R)-3-(3,4-Difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-2-oxo-5-phenyl-2,3-1H-benzo[e][1,4]diazepin-3-yl)butyramide

Formula:	C₃₁H₂₄F₃N₃O₃

MW:	543.5

Purity:	≥98%

Appearance:	White to off-white powder.

Solubility:	Soluble in DMSO.

Long Term Storage:	-20°C

Handling:	Hygroscopic. Protect from light.

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Product Literature References

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of a: I. Churcher, et al.; J. Med. Chem. 46, 2275 (2003), Abstract;