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N-Oxalylglycine

PHD inhibitor
 
ALX-270-412-M010 10 mg 48.00 USD
 
ALX-270-412-M050 50 mg 140.00 USD
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Competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).

Product Specification

Alternative Name:NOG
 
Formula:C4H5NO5
 
MW:147.1
 
CAS:5262-39-5
 
Purity:≥98% (1H-NMR)
 
Identity:Determined by 1H-NMR and 13C-NMR.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Hygroscopic.
 
270-412
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270-412

Product Literature References

Structural basis for human PHF2 Jumonji domain interaction with metal ions: J.R. Horton, et al.; J. Mol. Biol. 406, 1 (2011), Abstract;
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases: J.R. Horton, et al.; Nat. Struct. Mol. Biol. 17, 38 (2010), Abstract;
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives: C.J. Cunliffe, et al.; J. Med. Chem. 35, 2652 (1992), Abstract;

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