Useful negative control for the PI(3)K (phosphoinositide 3-kinase) inhibitor LY-294,002 (Prod. No. BML-ST420). Does not inhibit PI(3)K even at concentrations
Product Details
| Alternative Name: | 2-(4-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one |
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| Formula: | C19H18N2O2 |
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| MW: | 306.4 |
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| CAS: | 154447-38-8 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway: T.W. Poh and S. Pervaiz; Cancer Res.
65, 6264 (2005),
Abstract;
Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils: J. Ding, et al.; J. Biol. Chem.
270, 11684 (1995),
Abstract;
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