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Olomoucine, N9-Isopropyl-

CDK/cyclin inhibitor
 
ALX-270-397-M001 1 mg 30.00 USD
 
ALX-270-397-M005 5 mg 88.00 USD
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Replaces Prod. #: BML-CC202

Inhibitor of CDK1/cyclin B (IC50=2µM) and CDK5/p35 (IC50=3µM). Similar to olomoucine, but more potent.

Product Specification

Alternative Name:6-Benzylamino-2-(2-hydroxyethylamino)-9-Isopropylpurine
 
Formula:C17H22N6O
 
MW:326.4
 
CAS:158982-15-1
 
Purity:≥98% (HPLC, TLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in DMSO or dimethyl formamide; sparingly soluble in methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for 3 months when stored at -20°C.
 
270-397
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270-397

Product Literature References

Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis: F.I. Raynaud, et al.; Mol. Cancer Ther. 3, 353 (2004), Abstract;
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994), Abstract;

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