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Olomoucine II

CDK/cyclin inhibitor
 
ALX-270-396-M001 1 mg 30.00 USD
 
ALX-270-396-M005 5 mg 134.00 USD
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Selective inhibitor of CDK1/cyclin B (IC50=20nM). Potent cytotoxin in tumor cells: IC50=5.3µM against MCF7 cells, IC50=11.1µM against K562 cells, IC50=3.0µM against CEM cells, IC50=6.3µM against HOS cells, and IC50=6.3µM against G361 cells.

Product Specification

Alternative Name:6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine
 
Formula:C19H26N6O2
 
MW:370.5
 
CAS:500735-47-7
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white crystalline solid.
 
Solubility:Soluble in DMSO, dimethyl formamide or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
270-396
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270-396

Product Literature References

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor: V. Krystof, et al.; Cell Mol. Life Sci. 62, 1763 (2005), Abstract;
Synthesis and biological activity of olomoucine II: V. Krystof, et al.; Bioorg. Med. Chem. Lett. 12, 3283 (2002), Abstract;

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