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NU2058

CDK inhibitor
 
ALX-270-394-M005 5 mg 87.00 USD
 
ALX-270-394-M025 25 mg 349.00 USD
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Competitive inhibitor of CDK1/cyclin B (IC50=5µM) and CDK2/cyclin A (IC50=12µM). Pharmacologically distinct from the relative specific inhibitor of CDK1/2 roscovitine (Prod. No. BML-CC205).

Product Specification

Alternative Name:O6-Cyclohexylmethylguanine
 
Formula:C12H17N5O
 
MW:247.3
 
CAS:161058-83-9
 
Solubility:Soluble in water or DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-394
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270-394

Product Literature References

The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2: L.R. Harrison, et al.; Biochem. Pharmacol. 77, 1586 (2009), Abstract;
The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death: M. Ferguson, et al.; Cell Cycle 3, 80 (2004), Abstract;
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles: C.E. Arris, et al.; J. Med. Chem. 43, 2797 (2000), Abstract;

Related Products

(R)-Roscovitine 

CDK inhibitor
186692-46-6, ≥95% (HPLC, TLC) | Print as PDF
 
BML-CC205-0002 2 mg 74.00 USD
 
BML-CC205-0005 5 mg 167.00 USD
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