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CVT-313

CDK/cyclin inhibitor
 
ALX-270-393-M001 1 mg 74.00 USD
 
ALX-270-393-M005 5 mg 289.00 USD
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Specific inhibitor of CDK2/cyclin A (IC50=500nM) and CDK2/cyclin E (IC50=500nM). Also inhibits CDK1/cyclin B (IC50=4.2µM) and CDK4/cyclin D1 (IC50=215µM).

Product Specification

Alternative Name:6-(4-Methoxybenzylamino)-2-[bis(2-hydroxyethylamino)]-9-isopropylpurine
 
Formula:C20H28N6O3
 
MW:400.5
 
CAS:199986-75-9
 
Purity:≥98% (HPLC)
 
Appearance:White crystalline solid.
 
Solubility:Soluble in DMSO, dimethyl formamide or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from moisture.
 
270-393
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Product Literature References

Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling: R.N. Bhattacharjee, et al.; Mol. Cell. Biol. 21, 5417 (2001), Abstract; Full Text
CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation: E.E. Brooks, et al.; J. Biol. Chem. 272, 29207 (1997), Abstract; Full Text

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