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Elbfluorene

CDK1 inhibitor
 
ALX-270-389-M005 5 mg 218.00 USD
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Selective inhibitor of CDK1/cyclin B (IC50=4.2µM) with some P-glycoprotein-modulating properties (inhibitory activity ratio 1.26 at 7µM). Weakly inhibits CDK5/p25 (6% inhibition at 10µM) with no effect on CDK2/cyclin E and CDK4/cyclin D1 (IC50>100µM).

Product Specification

Alternative Name:3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine, 1-Aza-9-oxafluorene 5b
 
Formula:C19H13NO3
 
MW:303.3
 
Purity:≥95% (HPLC)
 
Appearance:Off-white to brownish powder.
 
Solubility:Soluble in DMSO. Insoluble in water or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
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Product Literature References

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lett. 15, 823 (2005), Abstract;
Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties: K. Brachwitz, et al.; J. Med. Chem. 46, 876 (2003), Abstract;

General Literature References

Probing novel 1-aza-9-oxafluorenes as selective GSK-3beta inhibitors: B. Voigt, et al.; ChemMedChem 3, 120 (2008), Abstract;

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