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Benfluorene

CDK1 inhibitor
 
ALX-270-388-M001 1 mg 89.00 USD
 
ALX-270-388-M005 5 mg 357.00 USD
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Selective inhibitor of CDK1 (IC50=28.8µM) with P-glycoprotein-modulating properties (inhibitory activity ratio 9.5 at 7µM). Weakly inhibits CDK5 (6% inhibition at 10µM) with no effect on CDK2 and CDK4 (IC50>100µM).

Product Specification

Alternative Name:Ethyl-(6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b])pyridine-3-carboxylate, 1-Aza-9-oxafluorene 5a
 
Formula:C20H15NO4
 
MW:333.3
 
Purity:≥95% (HPLC)
 
Appearance:Brownish powder.
 
Solubility:Soluble in DMSO or 100% ethanol. Insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-388
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270-388

Product Literature References

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties: K. Brachwitz, et al.; J. Med. Chem. 46, 876 (2003), Abstract;

General Literature References

Probing novel 1-aza-9-oxafluorenes as selective GSK-3beta inhibitors: B. Voigt, et al.; Chem. Med. Chem. 3, 120 (2008), Abstract;
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes: B. Voigt, et al.; Bioorg. Med. Chem. Lee. 15, 823 (2005), Abstract;

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