Selective inhibitor of CDK1/cyclin B (IC50=600nM), CDK5/p25 (IC50=400nM) and GSK-3β (IC50=1µM). Does not inhibit Cdc25 phosphatase activity (IC50>10µM).
Product Specification
| Formula: | C9H7N5 |
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| MW: | 185.2 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Red solid. |
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| CAS: | 40254-90-8 |
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| Solubility: | Soluble in DMSO. |
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| Long Term Storage: | +4°C |
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| Handling: | Packaged under inert gas. Protect from light. |
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Product Literature References
Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors: M.A. Ortega, et al.; Bioorg. Med. Chem.
10, 2177 (2002),
Abstract;