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Aloisine

Inhibitor of CDK and GSK
 
ALX-270-386-M001 1 mg 34.00 USD
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Potent, cell permeable, selective ATP-competitive inhibitor of CDK1/cyclin B (IC50=700nM), CDK5/p25 (IC50=1.5µM), and GSK-3 (IC50=920nM).

Product Specification

Alternative Name:RP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
 
Formula:C17H19N3O
 
MW:281.4
 
CAS:496864-15-4
 
Purity:≥95% (HPLC)
 
Identity:Identity determined by NMR.
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (200mg/ml) or methanol (200mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light. Packaged under inert gas.
 
270-386
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270-386

Product Literature References

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003), Abstract;

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