Aloisine

Inhibitor of CDK and GSK



ALX-270-386-M001	1 mg	29.00 USD

Potent, cell permeable, selective ATP-competitive inhibitor of CDK1/cyclin B (IC₅₀=700nM), CDK5/p25 (IC₅₀=1.5µM), and GSK-3 (IC₅₀=920nM).

Product Specification

Alternative Name:	RP106, 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine

Identity:	Identity determined by NMR.

Formula:	C₁₇H₁₉N₃O

MW:	281.4

Purity:	≥95% (HPLC)

Appearance:	Off-white solid.

CAS:	496864-15-4

Solubility:	Soluble in DMSO (200mg/ml) or methanol (200mg/ml).

Long Term Storage:	+4°C

Handling:	Packaged under inert gas. Protect from light.

Please mouse over

Product Literature References

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003), Abstract;