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Aloisine A

Inhibitor of CDK and GSK
 
ALX-270-385-M001 1 mg 42.00 USD
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Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC50=150nM), CDK2/cyclin A (IC50=120nM), CDK2/cyclin E (IC50=400nM), CDK5/p25 (IC50=200nM), CDK5/p35 (IC50=160nM) and GSK-3α (IC50=500nM). Also inhibits GSK-3β (IC50=650nM) and c-Jun N-terminal kinase (JNK) (IC50~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC50≥100µM). Blocks cell cycle in both G1 and G2 phase.

Product Specification

Alternative Name:RP107, 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
 
Formula:C16H17N3O
 
MW:267.3
 
CAS:496864-16-5
 
Purity:≥95% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
270-385
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270-385

Product Literature References

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003), Abstract;

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