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EB-47 . dihydrochloride . dihydrate

PARP-1 inhibitor
 
ALX-270-383-M001 1 mg 54.00 USD
 
ALX-270-383-M005 5 mg 210.00 USD
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Very potent and water soluble PARP-1 inhibitor (IC50=45nM, 100% inhibition at 200nM). Shows cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

Product Specification

Alternative Name:1-Piperazineacetamide,4-[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuron]-N-(2,3-dihydro-1H-isoindol-4-yl)-1-one . 2HCl . 2H2O
 
Formula:C24H27N9O6 . 2HCl . 2H2O
 
MW:537.5 . 73.0 . 36.0
 
Purity:≥95% (HPLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in water or DMSO.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from light. Packaged under inert gas.
 
270-383
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270-383

Product Literature References

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei: M. Schlesinger, et al.; Parasit. Vectors 9, 173 (2016), Application(s): Potency of inhibitors, Abstract; Full Text
Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation: H. Kleine, et al.; Mol. Cell 32, 57 (2008), Abstract;
The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1): P.G. Jagtap, et al.; Bioorg. Med. Chem. Lett. 14, 81 (2004), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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