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Ratjadone C (native)

Exportin-1 inhibitor
 
ALX-270-369-C005 5 µg 223.00 USD
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Cytotoxic secondary metabolite that inhibits cell growth of mammalian cell lines in the picomolar range (IC50=0.2ng/ml with L929 mouse cells) including multidrug resistant (MDR) HeLa cells (IC50=0.1ng/ml with KB-V1). Like leptomycin B (Prod. No. ALX-380-100), ratjadone C binds covalently to the nuclear export protein CRM1. It inhibits cargo protein binding to the leucine-rich nuclear export sequence and thereby blocks nuclear export.

Product Specification

Formula:C28H40O5
 
MW:456.6
 
Source:Isolated from Sorangium cellulosum.
 
Formulation:Solution in methanol (5µg in 1ml).
 
Purity:≥95% (HPLC)
 
Appearance:Clear liquid.
 
Solubility:Soluble in methanol (>50mg/ml). Sparingly soluble in aqueous buffers (up to 10µg/ml in PBS).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Acid and base sensitive. Unstable in acidic and alkaline buffer systems (pH <6 or >7). Stable in methanolic solution at -20°C.
 
Handling:Protect from light.
 
270-369
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270-369

Product Literature References

Ratjadones inhibit nuclear export by blocking CRM1/exportin 1: M. Koster, et al.; Exp. Cell. Res. 286, 321 (2003), Abstract;
The chemistry and biology of the leptomycin family: M. Kalesse & M. Christmann; Synthesis 2002, 981 (2002), Abstract;
Antibiotics from gliding bacteria, LXIII. Ratjadone: a new antifungal metabolite from Sorangium cellulosum: D. Schummer, et al.; Liebigs Ann. 685 (1995),
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physico-chemical and biological properties: K. Gerth, et al.; J. Antibiot. (Tokyo) 48, 973 (1995), Abstract;

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Leptomycin B 

Nuclear export inhibitor
87081-35-4, Isolated from Streptomyces sp., ≥96% (HPLC) | Print as PDF
 
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