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Pioglitazone

PPARγ activator
 
ALX-270-367-M001 1 mg 53.00 USD
 
ALX-270-367-M005 5 mg 124.00 USD
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Pioglitazone selectively activates PPARγ-1. It is about one tenth as potent as rosiglitazone (EC50~500nM for human and mouse PPARγ). In a transactivation assay using COS-1 cells transfected with full length human PPARα and RXRα, pioglitazone and rosiglitazone exhibit low level activation of PPARα at 1µM and 5.4- and 4.2-fold activation, respectively, at a concentration of 10µM.

Product Specification

Formula:C19H20N2O3S
 
MW:356.4
 
CAS:111025-46-8
 
MI:14: 7452
 
Purity:≥97% (HPLC)
 
Identity:Confirmed by 1H-NMR
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (2.5mg/ml) or dimethyl formamide (2.5mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Handling:Protect from moisture.
 
Scientific Background:Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (Prod. No. ALX-350-125) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands.
 
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Product Literature References

Effect of zinc supplements in the attenuated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart: S.K. Kansal, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 388, 635 (2016), Application(s): Cell culture, Abstract; Full Text
Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells: D. Gao, et al.; PLoS One 10, e0123724 (2015), Application(s): Cell Culture, Abstract; Full Text
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone: J. Sakamoto, et al.; BBRC 278, 704 (2000), Abstract;
The PPARs: from orphan receptors to drug discovery: T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000), Abstract;
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996), Abstract;
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995), Abstract; Full Text
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994), Abstract;

Related Products

Rosiglitazone 

Insulin sensitizing agent
122320-73-4, ≥97% (HPLC) | Print as PDF
 
ALX-350-125-M025 25 mg 114.00 USD
 
ALX-350-125-M100 100 mg 326.00 USD
Do you need bulk/larger quantities?
 

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