Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


PPARγ activator
ALX-270-367-M001 1 mg 54.00 USD
ALX-270-367-M005 5 mg 126.00 USD
Do you need bulk/larger quantities?
Pioglitazone selectively activates PPARγ-1. It is about one tenth as potent as rosiglitazone (EC50~500nM for human and mouse PPARγ). In a transactivation assay using COS-1 cells transfected with full length human PPARα and RXRα, pioglitazone and rosiglitazone exhibit low level activation of PPARα at 1µM and 5.4- and 4.2-fold activation, respectively, at a concentration of 10µM.

Product Specification

MI:14: 7452
Purity:≥97% (HPLC)
Identity:Confirmed by 1H-NMR
Appearance:White to off-white solid.
Solubility:Soluble in DMSO (2.5mg/ml) or dimethyl formamide (2.5mg/ml).
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Handling:Protect from moisture.
Scientific Background:Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (Prod. No. ALX-350-125) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands.
Please mouse over

Product Literature References

Effect of zinc supplements in the attenuated cardioprotective effect of ischemic preconditioning in hyperlipidemic rat heart: S.K. Kansal, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 388, 635 (2016), Application(s): Cell culture, Abstract; Full Text
Rosiglitzone Suppresses Angiotensin II-Induced Production of KLF5 and Cell Proliferation in Rat Vascular Smooth Muscle Cells: D. Gao, et al.; PLoS One 10, e0123724 (2015), Application(s): Cell Culture, Abstract; Full Text
Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone: J. Sakamoto, et al.; BBRC 278, 704 (2000), Abstract;
The PPARs: from orphan receptors to drug discovery: T.M. Willson, et al.; J. Med. Chem. 43, 527 (2000), Abstract;
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39, 665 (1996), Abstract;
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma): J.M. Lehmann, et al.; J. Biol. Chem. 270, 12953 (1995), Abstract; Full Text
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents: B.C. Cantello, et al.; J. Med. Chem. 37, 3977 (1994), Abstract;

Related Products


Insulin sensitizing agent
122320-73-4, ≥97% (HPLC) | Print as PDF
ALX-350-125-M025 25 mg 116.00 USD
ALX-350-125-M100 100 mg 333.00 USD
Do you need bulk/larger quantities?

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
PPAR Ligand
PPAR Activator
By catalog section:


Technical Service
Customer Service

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,