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PARP-1 inhibitor
 
ALX-270-365-M001 1 mg 52.00 USD
 
ALX-270-365-M005 5 mg 210.00 USD
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Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC50=450nM). Neuroprotectant.

Product Specification

Alternative Name:Thieno[2,3-c]isoquinolin-5-one
 
Formula:C11H7NOS
 
MW:201.2
 
CAS:420849-22-5
 
Purity:≥96% (HPLC)
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
270-365
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270-365

Product Literature References

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia: A. Chiarugi, et al.; J. Pharmacol. Exp. Ther. 305, 943 (2003), Abstract; Full Text
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors: R. Pellicciari, et al.; Farmaco 58, 851 (2003), Abstract;

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The PARP Family & ADP Ribosylation
The PARP Family & ADP Ribosylation
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