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3-(3,5-Di-tert-butyl-4-hydroxybenzylidenyl)indolin-2-one

Receptor tyrosine kinase (RTK) inhibitor
 
ALX-270-364-M005 5 mg 137.00 USD
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Receptor tyrosine kinase (RTK) inhibitor. Inhibits FLK-1 RTK (IC50~8µM) and EGF RTK. Consists of the E- and Z-isomers.

Product Specification

Formula:C23H27NO2
 
MW:349.5
 
Source:Synthetic.
 
CAS:40526-64-5
 
Purity:≥97% (1H-NMR, HPLC)
 
Identity:Determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.
 
Appearance:Yellow crystals.
 
Solubility:Soluble in DMSO (35mg/ml) or methanol (2.5mg/ml). Sparingly soluble in aqueous buffers (25µg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
 
Handling:Protect from light. Keep cool and dry.
 
270-364
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270-364

Product Literature References

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998), Abstract;

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