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3-(4-Hydroxybenzylidenyl)indolin-2-one

EGFR-2 inhibitor
 
ALX-270-363-M005 5 mg 216.00 USD
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Selective receptor tyrosine kinase (RTK) inhibitor. Inhibits FLK-1 RTK (IC50 ~3µM). Consists predominantly of the E-isomer, contains ~10% of the Z-isomer.

Product Specification

Formula:C15H11NO2
 
MW:237.3
 
Source:Synthetic.
 
CAS:293302-14-4
 
Purity:≥98%
 
Identity:Determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.
 
Appearance:Yellow crystals.
 
Solubility:Soluble in DMSO (> 50 mg/ml) or methanol (0.5mg/ml). Sparingly soluble in aqueous buffers (5µg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
 
Handling:Protect from light. Keep cool and dry.
 
270-363
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270-363

Product Literature References

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998), Abstract;

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