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3-(4-Isopropylbenzylidenyl)indolin-2-one

Receptor tyrosine kinase (RTK) inhibitor
 
ALX-270-362-M001 1 mg 58.00 USD
 
ALX-270-362-M005 5 mg 222.00 USD
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Non-selective inhibitor of receptor tyrosine kinases (RTKs). Inhibits PDGFR, FLK-1, EGFR, HER-2, IGF-1R RTKs (IC50 ~5-25µM). Consists primarily of the E-isomer; contains ~5% of the Z-isomer.

Product Specification

Formula:C18H17NO
 
MW:263.4
 
Source:Synthetic.
 
CAS:186611-55-2
 
Purity:≥98% (1H-NMR, HPLC)
 
Identity:Determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.
 
Appearance:Yellow crystals.
 
Solubility:Soluble in DMSO (>80mg/ml) or methanol (8mg/ml); sparingly soluble in aqueous buffers (25µg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Stable as a powder for at least 2 years when stored at +4°C in the dark. Stock solutions made in DMSO should be stored in the dark and used within one month.
 
Handling:Protect from light. Keep cool and dry.
 
270-362
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270-362

Product Literature References

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases: L. Sun, et al.; J. Med. Chem. 41, 2588 (1998), Abstract;

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