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TDZD-8

GSK-3β inhibitor
 
ALX-270-354-M005 5 mg 193.00 USD
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Highly selective, non-ATP competitive inhibitor of GSK-3β (IC50=2µM). Binds to the active site of GSK-3β. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase (PKA), and protein kinase C (PKC) (IC50>100µM).

Product Specification

Alternative Name:4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
 
Formula:C10H10N2SO2
 
MW:222.3
 
CAS:327036-89-5
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Handling:Protect from light. Keep under inert gas.
 
270-354
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270-354

Product Literature References

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease: A. Martinez, et al.; J. Med. Chem. 45, 1292 (2002), Abstract; Full Text

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