Replaces Prod. #: BML-GR244
Antagonist of PPARγ. Binds to PPARγ with an apparent Kd of 100µM.
Product Details
| Alternative Name: | Bisphenol A diglycidyl ether, 2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane |
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| Formula: | C21H24O4 |
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| MW: | 340.4 |
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| CAS: | 1675-54-3 |
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| Purity: | ≥85% |
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| Identity: | Determined by IR. |
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| Appearance: | Colorless viscous liquid. |
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| MeltingPoint: | 40-44°C |
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| Solubility: | Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide; insoluble in PBS, pH 7.2. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C. |
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| Scientific Background: | Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int.
26, 235 (2002),
Abstract;
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J.
362, 573 (2002),
Abstract;
Full Text
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem.
81, 1052 (2002),
Abstract;
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem.
275, 1873 (2000),
Abstract;
Full Text
