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BADGE

PPARγ inhibitor
 
ALX-270-353-G025 25 g 39.00 USD
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Replaces Prod. #: BML-GR244

Antagonist of PPARγ. Binds to PPARγ with an apparent Kd of 100µM.

Product Specification

Alternative Name:Bisphenol A diglycidyl ether, 2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
 
Formula:C21H24O4
 
MW:340.4
 
CAS:1675-54-3
 
Purity:≥85%
 
Identity:Determined by IR.
 
Appearance:Colorless viscous liquid.
 
MeltingPoint:40-44°C
 
Solubility:Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide; insoluble in PBS, pH 7.2.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.
 
Scientific Background:Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.
 
ALX-270-353 structure
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ALX-270-353 structure

Product Literature References

Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002), Abstract;
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002), Abstract; Full Text
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002), Abstract;
A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000), Abstract; Full Text

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